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The endogenous androgens, testosterone (T) and dihydrotestosterone (DHT), are both steroidal AR agonists. In the early years (1950s) of development of AR ligands, research efforts were devoted solely to structural modification of endogenous steroids and led to the discovery of various synthetic steroids, including agonists and antagonists [1-3]. T and DHT are not available orally, so most of the early structural modifications were made to either improve the oral bioavailability of the steroidal ligands or to separate the androgenic and anabolic activities of androgens, cardarine mk677 stack. T esters and 17α-alkylated steroids are often used to improve either the duration of action or the bioavailability of steroidal androgens. T esters work as delayed-release forms of T, but produce inconsistent pharmacokinetic profiles that severely hamper their clinical use. CA 02543827 2006-04-26 WO 2005/120483 PCT/US2005/019788 [0079] A wasting condition or disor der is defined herein as a condition or disorder tllat is characterized, at least in part, by an abnoniial, progressive loss ofbod,y, organ or tissue mass, cardarine mk677 stack.
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